Front Cover: Synthesis and Vasorelaxant Activity of Nitrate−Coumarin Derivatives (ChemMedChem 21/2022)
نویسندگان
چکیده
The Front Cover shows the most active molecule of a series nitrate coumarins, coumarin-7-yl-methyl nitrate, that “magically” releases nitric oxide into bloodstream, leading to vasodilatory effect. Synthesized nitrate−coumarins show potent vasodilator activity on isolated rat aortic rings deprived endothelium, with higher effect those pre-contracted phenylephrine than potassium chloride. This suggests opening channels may be involved in their vasorelaxant mechanism action. design by Maria João Matos graphic components reused permission: Red blood cells flowing background ′Macrovector—Freepik.com′ available at Freepik; Tale composition magic wand and magician hat ′Starline—Freepik.com′ Freepik. More information can found Research Article et al.
منابع مشابه
Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivatives.
We have synthesized a new series of coumarins and furocoumarins and evaluated their vasorelaxant activity in rat aorta rings pre-contracted with noradrenaline or by depolarisation with high KCl. The new furocoumarins relax smooth vascular muscle with a profile similar to that of khellin (a furochromone that directly relaxes smooth muscle) and at a greater potency, suggesting that these compound...
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ژورنال
عنوان ژورنال: ChemMedChem
سال: 2022
ISSN: ['1860-7179', '1860-7187']
DOI: https://doi.org/10.1002/cmdc.202200567